Francesco Gentile

Gentile F, Chianca M, Bazan L, Sciarrone P, Chubuchny V, Taddei C, Poggianti E, Passino C, Emdin M, Giannoni A. Incremental prognostic value of echocardiography measures of right ventricular systolic function in patients with chronic heart failure. J Am Heart Assoc 2025 [In press]. DOI:. 10.1161/JAHA.124.038616. Gentile F, Giannoni A, Navari A, Degl'Innocenti E, Emdin M, Passino C. Acute right-sided transcutaneous vagus nerve stimulation improves cardio-vagal baroreflex gain in patients with chronic heart failure. Clin Auton Res 2024 [In Press]. DOI: 10.1007/s10286-024-01074-9. Gentile F, Emdin M, Passino C, Montuoro S, Tognini P, Floras JS, O’Neill J, Giannoni A. The chronobiology of human heart failure: clinical implications and therapeutic opportunities. Heart Fail Rev 2024 [In Press]. DOI: 10.1007/s10741-024-10447-1. Gentile F, Giannoni A, Aimo A, Castiglione V, Bramanti F, Iudice G, Degl’Innocenti E, Emdin M, Vergaro G, Passino C. Clinical and prognostic significance of central and obstructive apneas in patients with transthyretin cardiac amyloidosis. Eur J Prev Cardiol 2024: zwae297. DOI: 10.1093/eurjpc/zwae297 Gentile F, Sciarrone P, Panichella G, Bazan L, Chubuchny V, Buoncristiani F, Gasparini S, Taddei C, Poggianti E, Fabiani I, Aimo A, Petersen C, Passino C, Emdin M, Giannoni A. Echocardiographic derived forward left ventricular output improves risk prediction in systolic heart failure. J Am Soc Echocardiogr. 2024;37:937-946. DOI: 10.1016/j.echo.2024.06.008. Gentile F, Orlando G, Montuoro S, Ferrari Chen YF, Macefield V, Passino C, Giannoni A, Emdin M. Treating Heart Failure by Targeting the Vagus Nerve. Heart Fail Rev 2024; 29: 1201-1215. DOI: 10.1007/s10741-024-10430-w. Montuoro S, Gentile F, Giannoni A. Neuroimmune cross-talk in heart failure. Cardiovasc Res 2024 [In press]. Aimo A, Vergaro G, Castiglione V, Fabiani I, Barison A, Gentile F, Ferrari Chen YF, Giorgetti A, Genovesi D, Buda G, Franzini M, Piepoli M, Moscardini S, Rapezzi C, Fontana M, Passino C, Emdin M. Wild-Type Transthyretin Cardiac Amyloidosis is Not Rare in Elderly Subjects: the CATCH Screening Study. Eur J Prev Cardiol 2024 Mar 8:zwae093. DOI: 10.1093/eurjpc/zwae093 Vergaro G, Aimo A, Gentile F, Mandoli GE, Focardi M, Castiglione V, Giannoni A, Panichella G, Fornaro A, Carluccio E, Liga R, Salatin M, Passino C, Cameli M, Cappelli F, Di Mario C, Emdin M. Eligibility for vericiguat in a real-world, contemporary heart failure population. ESC Heart Fail 2024 [E-pub Ahead of print]. DOI: 10.1002/ehf2.14767. D’Alesio G, Stumpp L, Sciarrone P, Navari A, Gentile F, Borrelli C, Ballanti S, Innocenti E, Carrasco A, Costa AC, Andrade A, Mannini A, Macefield V, Emdin M, Passino C, Mazzoni A, Giannoni A, Oddo CM. An open computational toolbox to analyze microneurographic sympathetic data. Biophys Rev 2024; 5: 021401. DOI: 10.1063/5.0202385. Emdin M, Gentile F, Giannoni A. Metabolic Surgery Saves Lives: Let's Treat Obesity to Reduce the Perils of Obstructive Sleep Apnea. J Am Coll Cardiol 2024; 84: 1061-1063. DOI: 10.1016/j.jacc.2024.07.012. Palagini L, Gentile F, Emdin M. Anxiety, depression and chronic heart failure: Bad companions getting worse over time. Int J Cardiol 2024:132409. DOI: 10.1016/j.ijcard.2024.132409. Emdin M, Gentile F, Giannoni A. Mandibular Advancement versus CPAP for Obstructive Sleep Apnea: Open Your Mouth Wide and Breathe. J Am Coll Cardiol 2024; 83:1773-1774. DOI: 10.1016/j.jacc.2024.03.374. Giannoni A, Passino C, Gentile F, Sciarrone P, Emdin M. Decoding Ticagrelor Dyspnea: Central Apnea Screening Before Drug Discontinuation. JACC Cardiovasc Interv 2024; 17: 450-451. DOI: 10.1016/j.jcin.2023.12.019. Gentile F, Buoncristiani F, Sciarrone P, Bazan L, Panichella G, Gasparini S, Chubuchny V, Taddei C, Poggianti E, Fabiani I, Petersen C, Lancellotti P, Passino C, Emdin M, Giannoni A. Left ventricular outflow tract velocity-time integral improves outcome prediction in patients with secondary mitral regurgitation. Int J Cardiol 2023: 392: 131272. DOI: 10.1016/j.ijcard.2023.131272. Giannoni A, Borrelli C, Gentile F, Sciarrone P, Spießhöfer J, Piepoli M, Richerson GB, Floras JS, Coats AJS, Javaheri S, Emdin M, Passino C. Autonomic and respiratory consequences of altered chemoreflex function: clinical and therapeutic implications in cardiovascular diseases. Eur J Heart Fail 2023; 25: 642-656. DOI: 10.1002/ejhf.2819. Chiusolo S, Bork CS, Gentile F, Lundbye-Christensen S, Harris WS, Schmidt EB, De Caterina R. Adipose tissue n-3/n-6 fatty acids ratios versus n-3 fatty acids fractions as predictors of myocardial infarction. Am Heart J 2023; 262: 38-48. DOI: 10.1016/j.ahj.2023.03.019. Di Cori A, Parollo M, Gentile F, Pistelli L, Vitale C, Della Volpe S, Giannotti Santoro M, Mazzocchetti L, De Lucia R, Canu A, Barletta V, Grifoni G, Segreti L, Bongiorni MG, Zucchelli G. Short and long-term outcomes of Lesion Index Guided-High Power Short Duration approach for atrial fibrillation ablation. J Clin Med 2023; 12: 4986. DOI: 10.3390/jcm12154986. Vergaro G, Del Franco A, Gentile F, Castiglione V, Aimo A, Saponaro F, Masotti S, Prontera C, Fusari N, Emdin M, Passino C. Intact fibroblast growth factor 23 tested by a fully automated assay: clinical correlates and prognostic value in chronic systolic heart failure. BMC Cardiovasc Disord 2023; 23: 433. DOI: 10.1186/s12872-023-03441-2. Castiglione V, Gentile F, Ghionzoli N, Chiriacò M, Panichella G, Aimo A, Vergaro G, Giannoni A, Passino C, Emdin M. Pathophysiological Rationale and Clinical Evidence for Neurohormonal Modulation in Heart Failure with Preserved Ejection Fraction. Card Fail Rev 2023;9:e09. DOI: 10.15420/cfr.2022.23 Gentile F, Sciarrone P, Buoncristiani F, Castiglione V, Bramanti F, Iudice G, Poletti R, Passino C, Emdin M, Giannoni A. Central apneas and cardiovascular diseases. G Ital Cardiol 2023;24: 701-710. DOI: 10.1714/4084.40680. Castiglione V, Morfino P, Gentile F, Airò E, Passino C, Giannoni A, Emdin M. Obstructive sleep apneas and cardiovascular diseases. G Ital Cardiol 2023 [E-pub Ahead of print]. Gentile F, Giannoni A, Emdin M, Fabiani I. More cardiopulmonary effort testing needed in HFpEF! Int J Cardiol 2023; 388: 131119. DOI: 10.1016/j.ijcard.2023.131119. Castiglione V, Gentile F, Vergaro G. Sarcopenia, Cachexia, and Heart Failure: a Last Mile to be Walked. Int J Cardiol 2023; 388: 131131. DOI: 10.1016/j.ijcard.2023.131131. Vergaro G, Gentile F, Modena M, Emdin M. Understanding family history of heart disease. A (good) patient interview vs. genetics. Eur J Prev Cardiol 2023; 30: 1569-1570. DOI: 10.1093/eurjpc/zwad159/7161694. Giannoni A, Gentile F, Emdin M. Beyond phrenic nerve stimulation to reduce the hypoxemic burden in central apneas: targeting chemoreflex. Int J Cardiol 2023; 383: 57-58. DOI: 10.1016/j.ijcard.2023.03.065. Fini L, Gentile F, De Caterina R. A case of Heyde’s Syndrome in a patient hospitalized for acute myocardial infarction. G Ital Cardiol 2023; 24: 661-664. DOI: 10.1714/4068.40535. Gentile F, Emdin M, Passino C, Giannoni A. Sex-Related Difference in Sympathetic Chemoreflex Response: Does It Matter in Disease Conditions? J Physiol 2022; 600: 4247-4248. DOI: 10.1113/JP283643. Gentile F, Borrelli C, Sciarrone P, Buoncristiani F, Spiesshoefer J, Bramanti F, Iudice G, Vergaro G, Emdin M, Passino C, Giannoni A. Central Apneas are More Detrimental in Female than in Male Patients with Heart Failure. J Am Heart Assoc 2022; 22: e024103. DOI: 10.1161/JAHA.121.024103. Gentile F, Fabiani I, Emdin M. Exercise Oscillatory Ventilation in Heart Failure and Brain-Lung-Heart-Muscle Crosstalk. Eur J Prev Cardiol 2022; 29: 1689-169. DOI: 10.1093/eurjpc/zwac145. Gentile F, Passino C, Emdin M, Giannoni A. Baroreflex Activation Therapy In Heart Failure: Targeting the Right Patient. Eur J Heart Fail 2022; 24: 1674-1676. DOI: 10.1002/ejhf.2627. Negro F and Gentile F (co-first authors), Rizza A, Giannoni A, Bianchi G, Clemente A, Emdin M, Palmieri C. Etiology, Clinical Presentation, and Management of Left Main Coronary Artery Aneurysms. J Card Surg 2022; 37: 3675-3686. DOI: 10.1111/jocs.16870. Vergaro G and Gentile F (co-first authors), Aimo A, Januzzi JLJ, Richards MA, Lam CSP, de Boer RA, Meems LMG, Latini R, Staszewsky L, Anand IS, Cohn JN, Ueland T, Gullestad L, Aukrust P, Brunner-La Rocca HP, Bayes-Genis A, Lupón J, Yoshihisa A, Takeishi Y, Egstrup M, Gustafsson I, Gaggin HK, Eggers KM, Huber K, Gamble GD, Ling LH, Leong KTG, Yeo PSD, Ong HY, Jaufeerally F, Ng TP, Troughton R, Doughty RN, Devlin G, Lund M, Giannoni A, Passino C, Emdin M. Circulating Levels and Prognostic Cut-offs of sST2, High-Sensitivity Troponin T, and NT-proBNP in Women versus Men with Chronic Heart Failure. ESC Heart Fail 2022; 9: 2084-2095. DOI: 10.1002/ehf2.13883. Baronti A and Gentile F (co-first authors), Manetti AC, Scatena A, Pellegrini S, Pucci A, Franzini M, Castiglione V, Maiese A, Giannoni A, Pistello M, Emdin M, Aquaro GD, Di Paolo M. Myocardial Infarction Following COVID-19 Vaccine Administration: Post Hoc Ergo Propter Hoc? Viruses 2022; 14: 1644. DOI: 10.3390/v14081644. Giannoni A, Gentile F, Passino C. Bioelectronic medicine and its applications in cardiology. Eur Heart J 2022; 43: 4453-4455. DOI: 10.1093/eurheartj/ehac343. Giannoni A, Gentile F, Buoncristiani F, Borrelli C, Sciarrone P, Spiesshoefer J, Bramanti F, Iudice G, Javaheri S, Emdin M, Passino C. Chemoreflex and Baroreflex Sensitivity Hold a Strong Prognostic Value in Chronic Heart Failure. JACC Heart Fail 2022; 10: 662-676. DOI: 10.1016/j.jchf.2022.02.006. Morrone D, Gentile F, Aimo A, Cameli M, Barison A, Picoi ME, Guglielmo M, Villano A, DeVita A, Mandoli GE, Pastore MC, Barillà F, Mancone M, Pedrinelli R, Indolfi C, Perrone Filardi P, Muscoli S, Tritto I, Pizzi C, Camici PG, Marzilli M, Crea F, R De Caterina, Pontone G, Neglia D, Lanza G, on behalf of the Coronary Physiopathology and Microcirculation Working Group and Cluster Imaging of the Italian Society of Cardiology (SIC). Perspectives in Noninvasive Imaging for Chronic Coronary Syndromes. Int J Cardiol 2022; 365: 19-29. DOI: 10.1016/j.ijcard.2022.07.038. Ghionzoli N, Gentile F, Del Franco AM, Castiglione V, Aimo A, Giannoni A, Burchielli S, Cameli M, Emdin M, Vergaro G. Current and Emerging Drug Targets in Heart Failure Treatment. Heart Fail Rev 2022; 27: 1119-1136. DOI: 10.1007/s10741-021-10137-2. Rossi A, Giannoni A, Nesti M, Notarstefano P, Castiglione V, Solarino G, Teresi L, Mirizzi G, Russo V, Panchetti L, Startari U, Ripoli A, Gentile F, Santoro A, Botto N, Casolo G, Sieira J, Pieroni M, Santangeli P, Emdin M, Piacenti M. Prognostic value of right ventricular refractory period 1 heterogeneity in type-1 Brugada electrocardiographic pattern. Europace 2022; 25: 651-659. DOI: 10.1093/europace/euac168. Chianca M, Fabiani I, Del Franco A, Grigoratos C, Aimo A, Panichella G, Giannoni A, Castiglione V, Gentile F, Passino C, Cipolla CM, Cardinale DM, Emdin M. Management and treatment of cardiotoxicity due to anticancer drugs: 10 questions and answers. Eur J Prev Cardiol 2022; 29: 2163-2172. DOI: 10.1093/eurjpc/zwac170 Di Cori A, Barletta V, Meola L, Parollo M, Mazzocchetti L, Carluccio M, Branchitta G, Cellamaro T, Gentile F, Segreti L, Viani S, Soldati E, De Lucia R, Zucchelli G, Bongiorni MG. Left atrial thrombus and smoke resolution in patients with atrial fibrillation under chronic oral anticoagulation. J Interv Card Electrophysiol 2022; 64: 773-781. DOI: 10.1007/s10840-022-01169-1. Gentile F, Aimo A, Passino C, Emdin M, Vergaro G. REPLY: Natriuretic Peptide-Based Risk Prediction and Assessment of Treatment Effect: Revisited in This Era. JACC Heart Fail 2021; 9: 942-943. DOI: 10.1016/j.jchf.2021.10.003 Gentile F, Castiglione V, De Caterina R. Coronary Artery Anomalies. Circulation 2021; 144: 983–996. DOI: 10.1161/CIRCULATIONAHA.121.055347. Gentile F, Ghionzoli N, Borrelli C, Vergaro G, Pastore MC, Cameli M, Emdin M, Passino C, Giannoni A. Epidemiological and Clinical Boundaries of Heart Failure with Preserved Ejection Fraction. Eur J Prev Cardiol 2021; zwab077. DOI: 10.1093/eurjpc/zwab077. Vergaro G and Gentile F (co-first authors), Meems LMG, Aimo A, Januzzi JLJ, Richards AM, Lam CSP, Latini R, Staszewsky L, Anand IS, Cohn JN, Ueland T, Gullestad L, Aukrust P, Brunner-La Rocca HP, Bayes-Genis A, Lupón J, Yoshihisa A, Takeishi Y, Egstrup M, Gustafsson I, Gaggin HK, Eggers KM, Huber K, Gamble GD, Ling LH, Leong KTG, Yeo PSD, Ong HY, Jaufeerally F, Ng TP, Troughton R, Doughty RN, Devlin G, Lund M, Giannoni A, Passino C, de Boer RA, Emdin M. NT-proBNP for Risk Prediction in Heart Failure: Identification of Optimal Cut-offs across Body-Mass Index Categories. JACC Heart Fail 2021; 9: 653-663. DOI: 10.1016/j.jchf.2021.05.014. Borrelli C, Gentile F, Sciarrone P, Spiesshoefer J, Navari A, Passino C, Emdin M, Giannoni A. Novel Drug Targets for Central Apneas in Heart failure: On the Road. Am J Respir Crit Care Med 2021; 204: 490-491. DOI: 10.1164/rccm.202104-0846LE. Spiesshoefer J, Gentile F, Borrelli C, and Giannoni A. Use of Hypocapnia for Improved Risk Stratification in Pulmonary Arterial Hypertension: Should We Return to Respiratory Pathophysiology? Int J Cardiol 2021; 329:208. DOI: 10.1016/j.ijcard.2020.12.015. Borrelli C, Gentile F, Mirizzi G, Passino C, Emdin M, Giannoni A. Hide and Seek. Ticagrelor and Central Apneas after Acute Coronary Syndrome. Sleep Med 2021; S1389-9457(21)00198-2. DOI: 10.1016/j.sleep.2021.03.027. Aimo A, Saccaro LF, Borrelli C, Fabiani I, Gentile F, Passino C, Emdin M, Piepoli MF, Coats AJS, Giannoni A. The Ergoreflex: how the Skeletal Muscle Modulates Ventilation and Cardiovascular Function in Health and Disease. Eur J Heart Fail 2021; 23: 1458-1467. DOI: 10.1002/ejhf.2298. Fabiani I, Aimo A, Grigoratos C, Castiglione V, Gentile F, Saccaro LF, Arzilli C, Cardinale D, Passino C, Emdin M. Oxidative Stress and Inflammation in Anthracycline Cardiotoxicity: Determinants of Disease and Possible Therapeutic Targets. Heart Fail Rev 2021; 26: 881-890. DOI: 10.1007/s10741-020-10063-9. Ghionzoli N, Sciaccaluga C, Mandoli GE, Vergaro G, Gentile F, D'Ascenzi F, Mondillo S, Emdin M, Valente S, Cameli M. Cardiogenic Shock and Acute Kidney Injury: the Rule Rather Than the Exception. Heart Fail Rev 2021; 26: 487-496. DOI: 10.1007/s10741-020-10034-0. Passino C, Sciarrone P, Vergaro G, Borrelli C, Spiesshoefer J, Gentile F, Emdin M, Giannoni A. Sacubitril–Valsartan Treatment is Associated with Decrease in Central Apneas in Patients with Heart Failure with Reduced Ejection Fraction. Int J Cardiol 2021; 330: 112-119. DOI: 10.1016/j.ijcard.2021.02.012. Gentile F, Aimo A, Forfori F, Catapano G, Clemente A, Cademartiri F, Emdin M, Giannoni A. COVID-19 and Risk of Pulmonary Fibrosis: the Importance of Planning Ahead. Eur J Prev Cardiol 2020; 27: 1442-1446. DOI: 10.1177/2047487320932695. Gentile F, Sciarrone P, Zamora E, De Antonio M, Santiago E, Domingo M, Aimo A, Giannoni A, Passino C, Codina P, Bayes-Genis A, Lupon J, Emdin M, Vergaro G. Body Mass Index and Outcomes in Ischemic vs. Non-Ischemic Heart Failure across the Whole Spectrum of Left Ventricular Ejection Fraction. Eur J Prev Cardiol 2020; 2: 2047487320927610. DOI: 10.1177/2047487320927610. Giannoni A and Gentile F (co-first authors), Sciarrone P, Borrelli C, Pasero G, Mirizzi G, Vergaro G, Poletti R, Piepoli MF, Emdin M, Passino C. Upright Cheyne-Stokes Respiration and Prognosis in Systolic Heart Failure. J Am Coll Cardiol 2020; 75: 2934-2946. DOI: 10.1016/j.jacc.2020.04.033. Giannoni A, Gentile F, Sciarrone P, Emdin M, and Passino C. REPLY: Upright Cheyne-Stokes Respiration in Heart Failure. An Ominous Sign of Cardiovascular Dysregulation. J Am Coll Cardiol 2020; 76: 2040–2041. DOI: 10.1016/j.jacc.2020.08.063. Gitto M, Gentile F, Nowbar AN, Chieffo A, Al-Lamee R. Gender-Related Differences in Clinical Presentation and Angiographic Findings in Patients with Ischemia and No Obstructive Coronary Artery Disease (INOCA): a Single-Center Observational Registry. Int J Angio 2020; 29: 250-255. DOI: 10.1055/s-0040-1709500. Giannoni A, Borrelli C, Gentile F, Mirizzi G, Coceani M, Paradossi U, Vergaro G, Bramanti F, Iudice G, Emdin M, Passino C. Central Apnoeas and Ticagrelor Related Dyspnoea in Patients with Acute Coronary Syndrome. Eur Hear J Cardiovasc Pharmacother 2020; 7: 180-188. DOI: 10.1093/ehjcvp/pvaa089. Giannoni A and Gentile F (co-first authors), Navari A, Borrelli C, Mirizzi G, Catapano G, Vergaro G, Grotti F, Betta M, Piepoli MF, Francis DP, Passino C, Emdin M. Contribution of the Lung to the Genesis of Cheyne-Stokes Respiration in Heart Failure: Plant Gain Beyond Chemoreflex Gain and Circulation Time. J Am Heart Assoc 2019; 8: e012419. DOI: 10.1161/JAHA.119.012419. Borrelli C, Gentile F, Sciarrone P, Mirizzi G, Vergaro G, Ghionzoli N, Bramanti F, Iudice G, Passino C, Emdin M, Giannoni A. Central and Obstructive Apneas in Heart Failure With Reduced, Mid-Range and Preserved Ejection Fraction. Front Cardiovasc Med 2019; 6: 125. DOI: 10.3389/fcvm.2019.00125.